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Test Name:
Salicylate, Serum
- SBMF No:
29151 - Performance Lab Name:
Automated Lab - Test Mnemonic:
SALIC- - ABN:
Not required - CPT Code:
80196 - LOINC Code:
4024-6 - Also Known As:
Aspirin
Acetylsalicylic Acid
ASA
Salicylic Acid - Spec Type:
Serum - Spec Container:
Red top (serum) tube - Pref Vol:
0.5 mL - Min Vol:
0.2 mL - Fasting:
No - Spec Collect:
Do not use gel-barrier tubes for specimen collection
Routine venipuncture
Collect sample 1-3 hours after an oral dose for therapeutic drug monitoring - Spec Process:
Serum sample tubes, clot 30 minutes
Promptly centrifuge 15 minutes
If sample will not be transported on day collected, transfer serum or plasma to separate plastic tube - Spec Store Transport:
Refrigerated (24 hours) or frozen - Spec Stability:
24 hours refrigerated (2-8°C)
Greater than 24 hours, freeze (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Methodology:
Reaction with ferric nitrate in acidic medium to form iron complex - Use:
Detect use
Evaluate therapeutic effect or possible toxicity of salicylate ingestion - Clinical Significance:
Aspirin (acetylsalicylic acid or salicylate) has analgesic, antipyretic, and anti-inflammatory properties. Because of these therapeutic benefits and the general lack of serious side effects at normal doses, salicylate as aspirin is widely available.
Aspirin interferes with platelet aggregation and thus prolongs the bleeding time. Due to this platelet inhibitory activity, low-dose aspirin has been recommended as prophylactic therapy for some people at risk for thromboembolic disease.
There is also an epidemiological association between aspirin ingestion and Reye’s syndrome in children and adolescents with viral infections) e.g., varicella and influenza). Aspirin use is therefore contra-indicated in these patients.The symptoms of salicylate intoxication include tinnitus, diaphoresis, hyperthermia, hyperventilation, nausea, vomiting, and acid-base disturbances. CNS effects include lethargy, disorientation, and, in severe cases, coma and seizures. - Reference Range:
Antipyretic/Analgesic:
Anti-inflammatory:
Toxic Concentrations:2-10 mg/dL
10-25 mg/dL
≥ 36 mg/dL - Critical High Value:
≥ 36 mg/dL - Day Run:
Sun-Sat (daily) - Time Run:
As received - Time Reported:
4 hours - Test Type:
TOX-TDM
