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Test Name:
Iron and Iron Binding Capacity, Serum

• SBMF No:
  29100
• Performance Lab Name:
  Automated Lab
• Test Mnemonic:
  IRONP
• ABN:
  May be required – Medical Necessity
• CPT Code:
  83540; 83550
• LOINC Code:
  2501-5; 2500-7; 2498-4; 2502-3
• Test Includes:
  Iron, Total, Serum
  Total Iron Binding Capacity (TIBC)
  Unsaturated Iron Binding Capacity (UIBC)
  Percent Saturation
• Also Known As:
  IBC (Iron Binding Capacity)
  TIBC (Total Iron Binding Capacity)
  Serum Iron
• Also See:
  30055 Ferritin
  28171 Transferrin, Serum
• Spec Type:
  Serum
• Spec Container:
  Gold top (SST) or red top (serum) tube
• Alt Spec Type:
  Plasma
• Alt Spec Container:
  Green top (lithium heparin) tube
• Pref Vol:
  1.0 mL
• Min Vol:
  0.3 mL
• Fasting:
  No
• Patient Prep:
  Document on requisition if patient received iron therapy
  Document on requisition if patient received recent transfusion
• Spec Collect:
  Routine venipuncture
  When possible, collect specimen prior to patient recovering therapeutic iron transfusion
  Wait at least 4 days after any transfusion to collect specimen
• Spec Process:
  Serum sample tubes, clot 30 minutes
  Promptly centrifuge 15 minutes
  Immediately transfer serum or plasma to separate plastic tube
• Spec Store Transport:
  Refrigerated
• Spec Stability:
  1 week refrigerated (2-8°C)
• Spec Reject:
  Hemolyzed sample
• Methodology:
  Photometric
• Use:
  Used to diagnosis and treatment of diseases such as iron deficiency anemia, hemochromatosis (a disease associated with widespread deposit in the tissue of the two iron-containing pigments, hemosiderin and hemofuscin, and characterized by pigmentation of skin), and chronic renal disease
• Clinical Significance:
  Ingested iron is mainly absorbed in the form of Fe2+ in the duodenum and upper jejunum. The trivalent form and the heme-bound Fe2+-component of iron in food have to be reduced by vitamin C. About 1 mg of iron is assimilated daily. Upon reaching the mucosal cells, Fe2+ ions become bound to transport substances. Before passing into the plasma, these are oxidized by ceruloplasmin to Fe3+ and bound to transferrin in this form. The transport of Fe ions in blood plasma takes place via transferrin-iron complexes. A maximum of 2 Fe2+ ions per protein molecule can be transported. Serum iron is almost completely bound to transferrin.Iron determinations are performed for the diagnosis and monitoring of microcytic anemia (e.g. due to iron metabolism disorders and hemoglobinopathy), macrocytic anemia (e.g. due to vitamin B12 deficiency, folic acid deficiency and drug-induced metabolic disorders of unknown origin) as well as normocytic anemias such as renal anemia (erythropoetin deficiency), hemolytic anemia, hemoglobinopathy, bone marrow disease and toxic bone marrow damage.
• Reference Range:
  

  Iron, Serum
  Male: 45-160 µg/dL
  Female: 30-160 µg/dL

  Percent Saturation
  Male: 12-70 %
  Female: 11-48 %

  TIBC
  Male: 247-406 µg/dL
  Female: 288-442 µg/dL

  UIBC
  Male: 84-287 µg/dL
  Female: 114-407 µg/dL

• Day Run:
  Sun-Sat (daily)
• Time Run:
  As received
• Time Reported:
  4 hours
• Test Type:
  CHEMISTRY