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Test Name:
Follicle Stimulating Hormone, Urine, 24-Hour
- SBMF No:
29093 - Performance Lab Name:
Automated Lab - Test Mnemonic:
U FSH24 - ABN:
Not required - CPT Code:
83001 - Test Includes:
Follicle Stimulating Hormone
Creatinine - Also Known As:
FSH, Urine - Also See:
30093 Follicle Stimulating Hormone, Serum - Spec Type:
Urine, 24-hour - Spec Container:
Plastic container with tightly fitting lid (no preservative) - Pref Vol:
20.0 mL aliquot from well-mixed 24-hour collection
Note: Send urine aliquot with notation of entire 24-hour urine volume on aliquot label and on requisition - Fasting:
No - Spec Collect:
To begin collection of timed specimen, have patient urinate, noting date and exact time
Discard this first portion of urine, but document date and time of voiding on container label and test requisition as "start" of timed specimen
Save all urine voided during designated time period, including portion voided at exact end of time period
IMPORTANT: Refrigerate entire specimen (2-8°C) during and after collection to prevent bacterial growth
Document date and time of final voiding on label and requisition as "end" of timed specimen - Spec Process:
Refrigerate entire specimen throughout collection
Upon completion of the collection, mix the entire specimen well and measure the 24-hour volume
Pour off 20.0 mL of urine into separate plastic tube(s)
Refrigerate urine aliquot and transport refrigerated
Send urine aliquot with notation of entire 24-hour urine volume on aliquot label and on requisition - Spec Store Transport:
Refrigerated - Spec Stability:
2 weeks refrigerated (2-8°C )
6 months frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Methodology:
Electrochemiluminescent Immunoassay (ECLIA) - Use:
Useful to distinguish primary gonadal failure from secondary (hypothalamic/pituitary) causes of menstrual disturbances and amenorrhea
Useful in defining menstrual cycle phases in infertility evaluation of women and testicular disfunction in men - Clinical Significance:
FSH (follicle stimulating hormone), like LH (luteinizing hormone), belongs to the gonadotropin family, FSH and LH synergistically regulate and stimulate the growth and function of the gonads (ovaries and testes). Similarly to LH, TSH and hCG, FSH is a glycoprotein consisting of two subunits (a- and b-chains). Its molecular weight is approximately 32,000 D. In women, the gonadotropins act within the hypothalamus-pituitary-ovary regulating circuit to control the menstrual cycle.FSH and LH are released in pulses from the gonadotropic cells of the anterior pituitary. Steroid hormones via negative feedback to the hypothalamus control the levels of the circulating hormones. In the ovaries FSH, together with LH, stimulates the growth and maturation of the follicle and hence also the biosynthesis of estrogens in the follicles. The FSH level shows a peak at mid-cycle, although this is less marked than with LH. Due to changes in ovarian function and reduced estrogen secretion, high FSH concentrations occur during menopause.In men, FSH serves to induce spermatogonium development. The determination of FSH is utilized in the elucidation of functional disorders within the hypothalamus-pituitary-gonad system. The determination of FSH together with LH is indicated for the following: congenital diseases with chromosome aberrations, amenorrhea (causes), polycystic ovaries (PCO) and menopausal syndrome. Depressed gonadotropin levels in men occur in azoospermia. - Reference Range:
Prepuberty: less than 1.6 IU/24 hours
Adult male: 3.0-21.7 IU/24 hours
Adult female: 1.6-7.9 IU/24 hours
Postmenopausal: greater than 7.9 IU/24 hours - Additional Test Info:
Record total specimen volume, collection times, and pH [if required] on test requisition - Day Run:
Sun-Sat (daily) - Time Run:
As received - Time Reported:
4 hours - Test Type:
HORMONE
