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Test Name:
HDL Cholesterol
- SBMF No:
29047 - Performance Lab Name:
Automated Lab - Test Mnemonic:
HDL CHOL - ABN:
May be required – Medical Necessity - CPT Code:
83718 - LOINC Code:
2085-9 - Also Known As:
High Density Lipoprotein Cholesterol
Cholesterol, High Density - Also See:
29042 LDL Cholesterol
29241 Cholesterol, Total
29243 Triglycerides
29048 Lipid Panel - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Alt Spec Type:
Plasma - Alt Spec Container:
Green top (lithium heparin) tube - Pref Vol:
2.0 mL - Min Vol:
1.0 mL - Fasting:
Yes - Patient Prep:
Fasting at least 12 hours - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube
Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube - Spec Store Transport:
Refrigerated - Spec Stability:
1 week refrigerated (2-8°C)
1 month frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Remarks:
Preferred specimen is primary serum sample contained in properly centrifuged SST (gel barrier) tube - Methodology:
Enzymatic - Use:
Determine the potential risk factor for coronary artery disease - Clinical Significance:
This test is used in the investigation of lipid status in suspected hyperlipidemia and as an assessment of risk for atherosclerosis, especially coronary artery disease. Low levels of HDL and high levels of LDL cholesterol are associated with an increased risk of atherosclerotic vascular disease. LDL levels are reduced for up to 8 weeks with acute illness (e.g., myocardial infarction, acute infection) and assays should not be performed during this time.Cholesterol, like oil, cannot dissolve in the blood unless it is combined with special proteins called lipoproteins. (Without combining with lipoproteins, cholesterol in the blood will turn into a solid substance.) The cholesterol that is secreted by the liver into the blood is combined either with very low-density lipoproteins (VLDL) or high-density lipoproteins (HDL). VLDL cholesterol is then metabolized in the bloodstream to produce LDL cholesterol. The cholesterol combined with low-density lipoprotein is called LDL cholesterol, and the cholesterol combined with high-density lipoproteins is called HDL cholesterol.HDL is termed the “good cholesterol” because HDL cholesterol particles prevent atherosclerosis by extracting cholesterol from the artery walls and disposing of them through the liver. Thus, high levels of LDL cholesterol and low levels of HDL cholesterol (high LDL/HDL ratios) are risk factors for atherosclerosis, whereas low levels of LDL cholesterol and high level of HDL cholesterol (low LDL/HDL ratios) are desirable.A protective substance utilized for prediction of coronary arterial disease, especially useful in individuals with high serum cholesterol levels. Low HDLC is an important predictor of risk of coronary atherosclerosis and coronary heart disease. HDL may act as a protective scavenger molecule (reverse cholesterol transport). The liver is the major site of cholesterol excretion. - Reference Range:
40-85 mg/dL - Day Run:
Sun-Sat (daily) - Time Run:
As received - Time Reported:
4 hours - Test Type:
LIPID
