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Test Name:
IgG Subclass 3


  • SBMF No:
    28290
  • Performance Lab Name:
    Manual Lab
  • Test Mnemonic:
    IGG SUBCL3
  • ABN:
    Not required
  • CPT Code:
    82787
  • LOINC Code:
    2468-7
  • Also Known As:
    Immunoglobin G Subclass 3
    IgG3
  • Also See:
    28297 – IgG Subclasses 1-4
  • Spec Type:
    Serum
  • Spec Container:
    Gold top (SST) or red top (serum) tube
  • Pref Vol:
    0.5 mL
  • Min Vol:
    0.3 mL
  • Fasting:
    No
  • Spec Collect:
    Routine venipuncture
  • Spec Process:
    Clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum to separate plastic tube
    Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube
  • Spec Store Transport:
    Refrigerated
  • Spec Stability:
    8 days refrigerated (2-8°C)
  • Spec Reject:
    Hemolyzed or lipemic sample
  • Methodology:
    Nephelometry
  • Use:
    A second order test for evaluation of selected patients with humoral or combined immunodeficiency
    Also useful in some patients with hypogammaglobulinemia and those with possible immunodeficiency and normal total IgG levels.
  • Clinical Significance:

    There are four IgG subclasses, which account for approximately 75-80% of total serum immunoglobulin. The subclasses (IgG1 through IgG4) show different properties, including ability to fix complement, to bind to macrophages and to pass through the placenta. Of total IgG, 65% is IgG1, 25% is IgG2, 6% is IgG3 and 4% is IgG4. Decreased concentrations of IgG subclasses may occur in the context of hypogammaglobulinemia (i.e. common variable immunodeficiency, where all Ig classes are affected) or deficiencies may be selective, usually involving subclass IgG2. Deficiency of IgG2 can occur as an isolated deficiency or in combination with deficiency of IgA and other IgG subclasses. Most patients with IgG2 deficiency present with recurrent infections, such as, sinusitis, otitis or pulmonary infections. Children with IgG2 deficiency often have deficient antibody response to polysaccharide antigens including bacterial antigens associated with Haemophilus influenza and Streptococcus pneumoniae.

    Comment: IgG subclasses measurement is not a first order test in patients suspected of having immunodeficiency. Quantitation of total IgG, IgA and IgM levels along with other first order tests (including lymphocyte counts, etc.) should be performed first.

  • Reference Range:

    Age (years)IgG 3 (mg/dL)
    0-2
    2-4
    4-6
    6-8
    8-10
    10-12
    12-14
    14-18
    Adults    		18.6-85
    17-68
    9.9-122
    15.5-85
    12.7-85
    17.3-173
    28.3-125
    23-196
    21.8-176
  • Day Run:
    Mon, Wed, Fri
  • Time Run:
    8:00 am
  • Time Reported:
    5:00 pm
  • Test Type:
    IMMUNOLOGY

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