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Test Name:
Parvovirus B19 IgG Antibody
- SBMF No:
28252 - Performance Lab Name:
Manual Lab - Test Mnemonic:
PARVO IGG - ABN:
Not required - CPT Code:
86747 - LOINC Code:
5273-8 - Also Known As:
Fifth Disease - Also See:
28254 Parvovirus B19 IgG & IgM Antibodies - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Alt Spec Type:
Plasma - Alt Spec Container:
Lavender top (EDTA) or green top (heparin) tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Routine venipuncture
Parallel testing is preferred
Label samples as: "acute" or "convalescent"
Convalescent samples must be received within 30 days from receipt of acute samples - Spec Process:
Serum sample tubes, clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum or plasma to separate plastic tube
Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube - Spec Store Transport:
Refrigerated - Spec Stability:
48 hours room temperature (20-30°C)
2 weeks refrigerated (2-8°C)
1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Methodology:
Enzyme Immunoassay (EIA) - Use:
Qualitative detection of parvovirus B19 IgG - Clinical Significance:
Parvovirus B19 (B19) is the only known human pathogenic parvovirus. B19 infection has a wide range of disease manifestations depending on the immunologic and hematologic status of the hosts. It causes erythema infectiosum (known as fifth disease or slapped-cheek disease), an innocuous rash illness, in normal and immunocompetent children. Occasionally, fifth disease leads to an acute symmetric polyarthropathy that can mimic rheumatoid arthritis especially in adults. In patients with underlying hemolytic disorders and/or increased erythropoiesis, infections lead to a temporary failure of red blood cell production and transient aplastic crisis. Persistent B19 viremia manifests as pure red cell aplasia and chronic anemia in the immuno-compromised host. The infection can lead to fetal death in utero, hydrops fetalis or congenital anemia in the fetus due to their immature immune system. B19 infection is common in childhood and it occurs in adult life as well. Detectable IgG is found in 50% of children by the age of 15 years and in more than 90% of elderly people. In immunocompetent patients, B19 DNA is only detectable in the first few days of infection. The diagnosis of acute B19 infection is therefore based on detection of IgM. IgM antibody remains detectable 2 to 3 months after infection. IgG usually is present by the seventh day of illness and remains detectable throughout life. - Reference Range:
- Parvovirus B19 IgG Antibody
- Negative: <0.6 IV
Equivocal: 0.6-1.1 IV
Positive: >1.1 IV
- Day Run:
Thu - Time Run:
6:00 am - Time Reported:
5:00 pm - Test Type:
INFECTIOUS ANTIBODY
