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Test Name:
Beta-2 Glycoprotein 1 IgG Antibody


  • SBMF No:
    28248
  • Performance Lab Name:
    Immunology
  • Test Mnemonic:
    B2GPI IGG
  • ABN:
    Not required
  • CPT Code:
    86146
  • LOINC Code:
    16135-6
  • Also Known As:
    GPA
  • Also See:
    44408 Beta-2 Glycoprotein 1 IgA Antibody
    28246 Beta-2 Glycoprotein 1 IgG & IgM Antibodies
    28251 Beta-2 Glycoprotein 1 IgM Antibody
  • Spec Type:
    Serum
  • Spec Container:
    Gold top (SST) or red top (serum) tube
  • Pref Vol:
    1.0 mL
  • Min Vol:
    0.5 mL
  • Fasting:
    No
  • Spec Collect:
    Routine venipuncture
  • Spec Process:
    Clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum to separate plastic tube
  • Spec Store Transport:
    Refrigerated
  • Spec Stability:
    1 week refrigerated (2-8°C)
    3 months frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Spec Reject:
    Severely lipemic or hemolyzed sample
    Plasma sample
  • Methodology:
    Enzyme-Linked Immunosorbent Assay (ELISA)
  • Use:
    Diagnose anti-phospholipid syndrome (APS) or assess the risk for thrombosis or unexplained, recurrent fetal loss
  • Clinical Significance:
    Beta-2glycoprotein 1 (beta-2 GP1) is a polypeptide synthesized in hepatocytes, endothelial cells and trophoblastic cells. Normal individuals may have low levels of IgG autoantibodies to beta-2 GP1. Pathologic levels of these autoantibodies occur in patients with various clinical signs and symptoms including thrombosis (arterial or venous), pregnancy morbidity (unexplained fetal death, premature birth, severe preeclampsia, or placental insufficiency), unexplained cutaneous circulatory abnormalities (livido reticularis or pyoderma gangrenosum), thrombocytopenia, hemolytic anemia, or non-bacterial thrombotic endocarditis. Beta-2 GP1 antibodies can also be seen with increased frequency in patients with systemic rheumatic diseases, particularly lupus erythematosus.
    Positive results for IgG and/or IgM beta-2 GP1 are consistent with anti-phospholipid syndrome (APS), but alone cannot be relied on to rule out APS. In addition, low levels of antibodies to beta-2 GP1 are of uncertain significance.
  • Reference Range:
    Beta-2 Glycoprotein 1 IgG Antibody
    0-20 SGU
  • Day Run:
    Thu
  • Time Run:
    8:00 am
  • Time Reported:
    5:00 pm, next day
  • Test Type:
    IMMUNOLOGY

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