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Test Name:
Treponema pallidum IgG Antibody, by MFI
- SBMF No:
28229 - Performance Lab Name:
Immunology - Test Mnemonic:
STS QUAL - ABN:
Not required - CPT Code:
86780 - LOINC Code:
47238-1 - Also Known As:
Qualitative Serum Syphilis Screen
Serological Test for Syphilis
STS
Syphilis IgG Antibody
Syphilis Serology - Also See:
28244 Treponema pallidum IgG Antibody, by MFI, with RPR Titer if Indicated - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube
Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube - Spec Store Transport:
Refrigerated - Spec Stability:
Room temperature (20-30°C): Unacceptable
1 week refrigerated (2-8°C)
1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Severely hemolyzed or lipemic sample - Methodology:
Multiplex Flow Immunoassay (MFI) - Use:
Qualitative screening test for Syphilis in serum - Clinical Significance:
Syphilis is a disease, usually sexually transmitted, caused by infection with the spirochetebacterium Treponema pallidum. Congenital transmission of Treponema pallidum bytransplacental passage from infected mothers, and contagion through blood transfusions havebeen also reported in the literature. Infection is systemic from the outset and the disease ischaracterized by periods of latency, often in excess of twenty years. Syphilis natural course isdivided into three phases. After an incubation period lasting about three weeks, a non-painful skinlesion (chancre) appears, often associated with regional lymphadenopathy (primary phase). Thedisease progresses into a secondary, disseminated, phase, accompanied by generalmucocutaneous lesions and lymphadenopathy. If a Treponema pallidum infection is allowed toprogress into the late phase of the disease, the secondary phase is followed by a period ofsubclinical infection (latent syphilis) that can be detected only by serological tests, and by a lateor tertiary phase, observed only in a small number of patients, characterized by progressivedisease. - Reference Range:
Negative: < 0.9 AI
Positive: >= 1.1 AI
Equivocal: 0.9 - 1.0 AI
AI = Antibody Index - Additional Test Info:
This test is not approved for use to screen blood, plasma, cell or tissue donors - Day Run:
Mon, Wed, Fri - Time Run:
8:00 am - Time Reported:
5:00 pm - Test Type:
INFECTIOUS ANTIBODY
