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Test Name:
Endomysial IgA Antibody, by IFA
- SBMF No:
28221 - Performance Lab Name:
Immunology - Test Mnemonic:
EMA IFA - ABN:
Not required - CPT Code:
86256 - LOINC Code:
27038-9 - Also Known As:
EMA IgA Titer
EMA Titer - Also See:
35198 Celiac Serology Profile
28013 Tissue Transglutaminase IgA Antibody, by ELISA, with Endomysial IgA Antibody IFA Titer if Indicated - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube
Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube - Spec Store Transport:
Refrigerated - Spec Stability:
1 week refrigerated (2-8°C)
Greater than 1 week, freeze (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Severely hemolyzed or lipemic sample - Methodology:
Indirect Fluorescent Antibody (IFA) - Use:
Approximately 70% of patients with dermatitis herpetiformis and almost 100% of patients with active celiac disease will demonstrate endomysial IgA antibodies. - Clinical Significance:
Celiac disease and dermatitis herpetiformis are two recognized forms of gluten sensitive enteropathy (GSE). A gluten-free diet controls GSE and associated risks. IgA endomysial antibodies (EMA) is one of the recommended serological tests shown to be useful in diagnosing these conditions.Selective IgA deficiency is increased tenfold in individuals with celiac disease, therefore, at least 3% of affected patients will test negative for this reason alone.
The endomysial antigen has been identified as the protein cross-linking enzyme known as tissue transglutaminase.
- Reference Range:
Negative - Day Run:
Thu, Sat - Time Run:
6:00 am - Time Reported:
5:00 pm - Test Type:
IMMUNOLOGY
