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Test Name:
Hepatitis C Virus Antibody, by ChLIA
- SBMF No:
28194 - Performance Lab Name:
Immunology - Test Mnemonic:
HCV AB- - ABN:
May be required – Medical Necessity - CPT Code:
86803 - LOINC Code:
13955-0 - Also Known As:
Anti-HCV
HCV Ab
Anti HCV - Also See:
28299 Hepatitis C Virus Antibody, by ChLIA, with HCV RNA, Quantitative, by RT-PCR if Indicated
28181 Hepatitis C Virus Antibody, Supplemental Immunoblot Assay (RIBA)
25106 Hepatitis C Virus RNA, Quantitative, by RT-PCR - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Alt Spec Type:
Plasma - Alt Spec Container:
Lavender top (EDTA) tube or green top (lithium heparin) tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Serum sample tubes, clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum or plasma to separate plastic tube - Spec Store Transport:
Refrigerated - Spec Stability:
1 week refrigerated (2-8°C)
Greater than 1 week, freeze (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Heat-inactivated sample - Methodology:
Chemiluminescent Immunoassay (ChLIA) - Use:
Differential diagnosis of acute hepatitis and evaluation of post-transfusion hepatitis - Clinical Significance:
Hepatitis C Virus (HCV) is a positive-sense, single-stranded RNA virus of the Flaviviridae family. The viral genome contains approximately 10,000 nucleotides that code for 3,000 amino acids. HCV accounts for 20 percent of all cases of acute hepatitis. Chronic infection is responsible for an estimated 8,000 to 10,000 deaths per year. Infection with HCV is now the leading reason for liver transplantation in the United States. The virus is blood-borne and is transmitted primarily by the parenteral route. Infection with HCV may occur in individuals who have received transfusions of blood or blood products prior to 1990, those who are undergoing renal dialysis or have received organ transplants, and those who have a history of intravenous drug use or intranasal cocaine use. - Reference Range:
Non-Reactive
Interpretive Data:
All reactive screens should be confirmed by HCV PCR (25106). A PCR result of NONE DETECTED with an initial reactive screen suggests either a false-reactive screen or a past HCV infection. HCV RIBA (28181) is recommended to further distinguish these two conditions. An HCV PCR result of DETECTED should be followed by HCV genotyping (36123). - Additional Test Info:
This test is not approved for use to screen blood, plasma, cell or tissue donors. - Day Run:
Tue, Thu, Sat - Time Run:
8:00 am - Time Reported:
5:00 pm - Test Type:
INFECTIOUS ANTIBODY
