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Test Name:
Hepatitis Panel, Acute

• SBMF No:
  28192
• Performance Lab Name:
  Immunology
• Test Mnemonic:
  HEP ACUTE
• ABN:
  May be required – Medical Necessity
• CPT Code:
  80074
• LOINC Code:
  13950-1; 5196-1; 13955-0; 5185-4
• Test Includes:
  Hepatitis A IgM Antibody
  Hepatitis B Core IgM Antibody
  Hepatitis B Surface Antigen with Confirmation if Indicated
  Hepatitis C Antibody
• Also Known As:
  Acute Hepatitis Panel
• Also See:
  28214 Hepatitis A IgM Antibody
  28418 Hepatitis B Core IgM Antibody
  28183 Hepatitis B Surface Antigen with Confirmation if Indicated
  28194 Hepatitis C Antibody
• Spec Type:
  Serum
• Spec Container:
  Gold top (SST) or red top (serum) tube
• Alt Spec Type:
  Plasma
• Alt Spec Container:
  Lavender top (EDTA) tube
• Pref Vol:
  5.0 mL
• Min Vol:
  3.0 mL
• Fasting:
  No
• Spec Collect:
  Routine venipuncture
• Spec Process:
  Serum sample tubes, clot 30 minutes
  Promptly centrifuge 15 minutes
  Immediately transfer serum or plasma to separate plastic tube
  Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube
• Spec Store Transport:
  Refrigerated
• Spec Stability:
  5 days refrigerated (2-8°C)
  Greater than 5 days, freeze (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
• Spec Reject:
  Heparinized plasma or heat-inactivated sample
• Methodology:
  See individual test listings
• Use:
  Evaluate hepatitis to determine whether the genesis is hepatitis A, B, or C
• Clinical Significance:
  

  Acute Hepatitis A: Hepatitis A is an RNA virus that causes an acute self-limiting illness characterized by jaundice, fever, anorexia, and diarrhea. An acute infection can be determined with the detection of hepatitis A virus (HAV) IgM antibodies, which appear early in the course of infection. Rheumatoid factor can occasionally cause false positive results.

  Acute Hepatitis B: Hepatitis B is a DNA virus consisting of a nucleocapsid core and an outer protein coat, which contains the surface antigen (HBsAg). Symptomatic acute hepatitis develops in 25% of infected persons. An active hepatitis B virus (HBV) infection can be confirmed by the presence of HBsAg, which is the first serologic marker to appear. Typically, HBsAg is no longer detectable 1 to 3 months after onset of jaundice and rarely persists longer than 6 months.Hepatitis B core antibodies (IgM) can be used to establish acute infection in a smaller number of patients (fewer than 5%) whose HBsAg is below detectable limits.

  Acute Hepatitis C: Hepatitis C is a small, single-stranded RNA virus. Infections are typically asymptomatic. For patients who develop acute hepatitis, the symptoms are generally milder than in acute infection with HAV or HBV.Hepatitis C virus (HCV) antibodies are generally non-protective, but serve as markers of chronic infection. If the acute panel is entirely negative, HCV RNA testing should be considered.

  Also see:
  

• Reference Range:
  

  HEPATITIS ACUTE PANEL
  	Anti-HAV, IgM Anti-HBc, IgM Hep B Surf Ag Anti-HCV		NON REAC NON REAC NON REAC NON REAC
  Anti-HBc, IgM
  	Interpretation:
  Reactive: Equivocal: Nonreactive:		Indicative of recent exposure to HBcAg. Consider retesting patient with another sample in 1-2 weeks. Usually indicates absence of recent infection.

• Additional Test Info:
  This test should be used for clinical purposes and is not approved to screen blood, plasma, cell or tissue donors.
• Day Run:
  Tue, Thu, Sat
• Time Run:
  8:00 am
• Time Reported:
  5:00 pm if neg
• Test Type:
  PANEL