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Test Name:
Hepatitis A Virus Total Antibodies
- SBMF No:
28178 - Performance Lab Name:
Immunology - Test Mnemonic:
HEP A - ABN:
May be required – Medical Necessity - CPT Code:
86708 - LOINC Code:
20575-7 - Test Includes:
HAV Total Antibodies (total of IgG antibodies combined with IgM antibodies) - Also Known As:
Anti-HAV
HAV Total Abs - Also See:
28214 Hepatitis A Virus IgM Antibody
28280 Hepatitis A Virus Total Antibodies, with IgM Antibody if indicated - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Alt Spec Type:
Plasma - Alt Spec Container:
Lavender top (EDTA) tube or green top (lithium or sodium heparin) tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Serum sample tubes, clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum or plasma to separate plastic tube
Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube - Spec Store Transport:
Refrigerated - Spec Stability:
5 days refrigerated (2-8°C)
Greater than 5 days, freeze (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Heat-inactivated sample - Methodology:
Chemiluminescent Immunoassay (CLIA) - Use:
Detect presence of total IgG & IgM HAV antibodies to diagnose either a current or recent HAV infection (IgM specific) or to diagnose a previous HAV infection (IgG specific); evaluate hepatitis - Clinical Significance:
The serologic diagnosis of acute hepatitis A virus (HAV) infection depends upon the demonstration of IgM-specific anti-HAV. This antibody usually appears about 4 weeks after infection and may persist for up to 4 months after the onset of clinical symptoms. The presence of IgG or total (IgM and IgG) antibody indicates past infection or immunization and associated immunity. The total assay detects both IgG and IgM antibodies, but does not differentiate between them. The Hepatitis A Antibody, IgM assay is appropriate when acute Hepatitis A infection is suspected. The FDA licensed an HAV vaccine in 1995.Total anti-HAV is useful in determining the immune status of a patient. It is especially useful for those patients recently diagnosed with HCV infection. These patients should receive HAV vaccination if anti-HAV is negative.IgM anti-HAV is useful in the work-up of suspected acute viral hepatitis. - Reference Range:
Anti-HAV, total: Non-Reactive - Day Run:
Tue, Thu, Sat - Time Run:
8:00 am - Time Reported:
5:00 pm - Test Type:
INFECTIOUS ANTIBODY
