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Test Name:
Varicella-Zoster Virus IgM Antibody, Serum


  • SBMF No:
    28176
  • Performance Lab Name:
    Immunology
  • Test Mnemonic:
    VZV M
  • ABN:
    Not required
  • CPT Code:
    86787
  • LOINC Code:
    8048-1
  • Also Known As:
    VZV IgM Antibody
    Chicken Pox Virus IgM Antibody
    Herpes Zoster IgM Antibody
    Human Herpesvirus 3 (HHV-3) IgM Antibody
  • Also See:
    28175 Varicella-Zoster Virus IgG Antibody
  • Spec Type:
    Serum
  • Spec Container:
    Gold top (SST) or red top (serum) tube
  • Pref Vol:
    1.0 mL
  • Min Vol:
    0.5 mL
  • Fasting:
    No
  • Spec Collect:
    Routine venipuncture
  • Spec Process:
    Clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum to separate plastic tube
    Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube
  • Spec Store Transport:
    Refrigerated (48 hours) or frozen
  • Spec Stability:
    48 hours refrigerated (2-8°C)
    Greater than 48 hours, freeze (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Spec Reject:
    Hemolyzed, lipemic, or icteric sample
  • Methodology:
    Enzyme-Linked Immunosorbent Assay (ELISA)
  • Use:
    Diagnose clinical infections with varicella or herpes zoster
  • Clinical Significance:
    Varicella, more commonly known at Chickenpox and Herpes Zoster, are the two known clinical manifestations, which can be produced by infection with a common etiologic agent, Varicella-Zoster virus (VZV).
  • Reference Range:
    <=0.90 = Negative, no detectable antibody.
    0.91-1.09 = Equivocal, results inconclusive; submit new specimen.
    >=1.10 = Positive, indicative of current or recent infection.
  • Additional Test Info:

    The results of ELISA performed on serum from immunosuppressed patients must be interpreted with caution.

    Negative test results cannot rule out the possibility of an active Herpes zoster infection, but positive results are confirmatory.

    The presence of IgM antibody in neonate’s serum can be considered indicative of congenital infection only if there has not been placental leakage.

    This test is not intended for the determination of immune states. It is intended for the determination of person’s antibody response to indicate active infection to VZV (primary or reactivation) and not an indication of immunity.

  • Day Run:
    Thu
  • Time Run:
    8:00 am
  • Time Reported:
    5:00 pm
  • Test Type:
    INFECTIOUS ANTIBODY

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