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Test Name:
Varicella-Zoster Virus IgG Antibody, Serum or Plasma


  • SBMF No:
    28175
  • Performance Lab Name:
    Immunology
  • Test Mnemonic:
    VZV G
  • ABN:
    Not required
  • CPT Code:
    86787
  • LOINC Code:
    8047-3
  • Also Known As:
    VZV IgG Antibody
    Chicken Pox Virus IgG Antibody
    Herpes zoster IgG Antibody
    Human Herpesvirus 3 (HHV-3) IgG Antibody
  • Also See:
    28176 Varicella-Zoster Virus IgM Antibody, Serum
  • Spec Type:
    Serum
  • Spec Container:
    Gold top (SST) or red top (serum) tube
  • Alt Spec Type:
    Plasma
  • Alt Spec Container:
    Lavender top (EDTA) or green top (sodium heparin) tube
  • Pref Vol:
    1.0 mL
  • Min Vol:
    0.25 mL
  • Fasting:
    No
  • Spec Collect:
    Routine venipuncture
  • Spec Process:
    Serum sample tubes, clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum or plasma to separate plastic tube
    Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube
  • Spec Store Transport:
    Refrigerated
  • Spec Stability:
    1 week refrigerated (2-8°C)
    Greater than 1 week, freeze (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Spec Reject:
    Contaminated, icteric, lipemic, hemolyzed or heat-inactivated samples
  • Methodology:
    Multiplex Flow Immunoassay (MFI)
  • Use:
    Diagnose clinical infections with varicella or herpes zoster
    Assess immune status of individuals exposed to varicella, especially pregnant women
  • Clinical Significance:
    Varicella (i.e., chickenpox) is a highly contagious disease caused by Varicella-zoster virus (VZV). VZV causes a systemic infection that usually results in lifetime immunity. In otherwise healthy persons, clinical illness after re-exposure is rare. However, as with other viral diseases, re-exposure to wild-type VZV may lead to reinfection that boosts antibody titers without causing clinical illness or detectable viremia.
  • Reference Range:

    ≤ 0.8 AI = Negative - No IgG antibodies specific to Varicella-zoster virus detected. Patient is presumed not to have had a previous exposure to Varicella-zoster virus through infection or vaccination
    0.9-1.0 AI = Equivocal results; obtain an additional sample for re-testing.
    ≥ 1.1 AI = Positive - IgG antibody to Varicella-zoster virus detected. This may indicate that the patient was exposed to Varicella-zoster virus through infection or vaccination.

    AI = Antibody Index

  • Additional Test Info:

    This test is not intended to be diagnostic for infectious disease and should only be utilized to establish serological status of the patient to Varicella-zoster virus.

    Positive results may be found in patients that have not been immunized. In these cases, the patient has a positive serological status to the infectious agent through natural exposure. False positive results may occur. Repeat testing or testing with a different device may be indicated in some settings, e.g., patients with low likelihood of prior infection or vaccination.

  • Day Run:
    Mon, Wed, Fri, Sat
  • Time Run:
    8:00 am
  • Time Reported:
    5:00 pm
  • Test Type:
    INFECTIOUS ANTIBODY

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