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Test Name:
Transferrin, Serum


  • SBMF No:
    28171
  • Performance Lab Name:
    Immunology
  • Test Mnemonic:
    TRANSF
  • ABN:
    May be required – Medical Necessity
  • CPT Code:
    84466
  • LOINC Code:
    3034-6
  • Also Known As:
    TRF
  • Also See:
    30055 Ferritin
    29100 Iron and Iron Binding Capacity, Serum
  • Spec Type:
    Serum
  • Spec Container:
    Gold top (SST) or red top (serum) tube
  • Pref Vol:
    1.0 mL
  • Min Vol:
    0.5 mL
  • Fasting:
    No
  • Spec Collect:
    Routine venipuncture
  • Spec Process:
    Clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum to separate plastic tube
    Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube
  • Spec Store Transport:
    Refrigerated
  • Spec Stability:
    38 days refrigerated (2-8°C)
    If frozen within 24 hours of collection, 1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Spec Reject:
    Hemolyzed sample
  • Methodology:
    Nephelometry
  • Use:
    Aid in the diagnosis of malnutrition, acute inflammation, infection, and red cell disorders, such as iron deficiency anemia
    Differentiate iron deficiency anemia (increased transferrin) from hypochromic microcytic anemias (index of nutritional normal to low transferrin) status
  • Clinical Significance:
    Transferrin serves to transport iron in the blood to the iron depots in the liver, spleen and bone marrow as well as to the iron-consuming organs, especially the hemopoetic tissues. Synthesis of transferring in the liver is influenced by the iron metabolism. Iron deficiency results in a rise in synthesis and, thus, in increasing serum concentrations, whereas, in iron overload synthesis is low. The determination of serum transferring is therefore used for diagnosing latent and manifest iron deficiency and iron overload. Transferrin is negative acute-phase protein, i.e., its serum concentrations are low during inflammatory and malignant disease.
  • Reference Range:
    200-360 mg/dL
  • Day Run:
    Mon, Wed, Fri
  • Time Run:
    8:00 am
  • Time Reported:
    5:00 pm
  • Test Type:
    HEMATOLOGY

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