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Test Name:
Ceruloplasmin
- SBMF No:
28165 - Performance Lab Name:
Immunology - Test Mnemonic:
CERULO - ABN:
Not required - CPT Code:
82390 - LOINC Code:
2064-4 - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube
Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube - Spec Store Transport:
Refrigerated - Spec Stability:
8 days refrigerated (2-8°C) - Spec Reject:
Hemolyzed sample - Methodology:
Nephelometry - Use:
Aid in the diagnosis of copper metabolism disorders; support the diagnosis of Wilson's disease; evaluate cirrhosis, liver disease, and central nervous system disease of obscure etiology; and neurological symptoms reflecting lesions of the lenticular nuclei - Clinical Significance:
Cerulopasmin is the main transport protein for copper in the blood. In addition, the protein exhibits enzymatic activity as an oxidase for various substrates. In Wilson’s disease and Menke’s syndrome (hereditary disorders of copper metabolism), the serum ceruloplasmin levels are markedly diminished, especially in homozygotes. Low levels of ceruloplasmin also occur in patients with hepatic insufficiency and protein loss syndrome. High serum levels of ceruloplasmin are observed in acute-phase reactions, during use of oral contraceptives and with cholestase. - Reference Range:
20-60 mg/dL - Day Run:
Mon, Wed, Fri - Time Run:
8:00 am - Time Reported:
5:00 pm - Test Type:
CHEMISTRY
