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Test Name:
Haptoglobin
- SBMF No:
28140 - Performance Lab Name:
Immunology - Test Mnemonic:
HAPTO - ABN:
Not required - CPT Code:
83010 - LOINC Code:
46127-7 - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube
Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube - Spec Store Transport:
Refrigerated - Spec Stability:
8 days refrigerated (2-8°C) - Spec Reject:
Hemolyzed sample - Methodology:
Nephelometry - Use:
Decreased levels occur with intravascular hemolysis, or extravascular hemolysis
Increased levels occur with acute or chronic inflammatory response, tissue destruction, and malignant neoplasms - Clinical Significance:
Haptoglobin binds hemoglobin, which is released during erythrocyte lysis. The haptoglobin/hemoglobin complex is rapidly eliminated from the blood stream. Increased release of hemoglobin due to intravascular hemoloysis results in a reduction in the haptoglobin concentrations, during severe hemolysis, to complete consumption of the haptoglobin. In children, haptoglobin has lower physiological serum concentrations and, therefore, is not suited for hemolysis testing. Haptoglobin is an acute-phase protein, which can develop very high serum levels during inflammatory conditions. - Reference Range:
30-200 mg/dL - Day Run:
Mon, Wed, Fri - Time Run:
8:00 am - Time Reported:
5:00 pm - Test Type:
HEMATOLOGY
