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Test Name:
IgA, Quantitative, Serum
- SBMF No:
28136 - Performance Lab Name:
Immunology - Test Mnemonic:
IGA - ABN:
Not required - CPT Code:
82784 - LOINC Code:
2458-8 - Also Known As:
Immunoglobulin A, Serum - Also See:
28130 IgA, IgG, and IgM Immunoglobulins, Quantitative, Serum - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
0.5 mL - Min Vol:
0.3 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube
Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube - Spec Store Transport:
Refrigerated - Spec Stability:
8 days refrigerated (2-8°C)
If frozen within 24 hours of collection, 3 months frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Hemolyzed sample - Methodology:
Nephelometry - Use:
Aid in the diagnosis of abnormal protein metabolism and the body's lack of ability to resist infectious agents
Evaluate humoral immunity; monitor therapy in myeloma and quantitate IgA; evaluate malabsorption syndrome - Clinical Significance:
Immunoglobulins are formed by plasma cells as a humoral immune response to contact of the immune system with antigens. The primary reaction after the initial contact is the formation of antibodies of the IgM class followed later by IgG and also IgA antibodies. Quantitative determination of the immunoglobulins can provide important information on the humoral immune status.
Decreased serum immunoglobulin concentrations occur in primary immunodeficiency conditions as well as in secondary immune insufficiencies, e.g., in advanced malignant tumors, lymphatic leukemia, multiple myeloma and Waldentrom's disease. Increased serum immunoglobulins concentrations occur due to polyclonal or ligoclonal Ig proliferation, e.g., in hepatic diseases (hepatitis, liver cirrhosis), acute and chronic infections, autoimmune diseases as well as in the cord blood of neonates with intra-uterine and perinatal infections. Monoclonal immunoglobulin proliferations in the serum are found e.g. in plasmacytomas, Waldenstrom's disease and heavy-chain disease. Monoclonal immunoglobulinemia requires detailed differential diagnostic investigations in addition to the quantitative determination.
- Reference Range:
0-12 months: 0-83 mg/dL
1-3 years: 20-100 mg/dL
4-6 years: 27-195 mg/dL
7-9 years: 34-305 mg/dL
10-11 years: 53-204 mg/dL
12-13 years: 58-359 mg/dL
14-15 years: 47-249 mg/dL
16-19 years: 61-348 mg/dL
≥20 years: 70-400 mg/dL - Day Run:
Mon, Wed, Fri - Time Run:
8:00 am - Time Reported:
5:00 pm - Test Type:
IMMUNOLOGY
