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Test Name:
IgG, Quantitative, Serum
- SBMF No:
28135 - Performance Lab Name:
Immunology - Test Mnemonic:
IGG - ABN:
Not required - CPT Code:
82784 - LOINC Code:
2465-3 - Also Known As:
Immunoglobulin G, Serum - Also See:
28130 IgA, IgG, and IgM Immunoglobulins, Quantitative, Serum - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube
Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube - Spec Store Transport:
Refrigerated - Spec Stability:
8 hours room temperature (20-30°C)
1 week refrigerated (2-8°C)
If frozen within 24 hours of collection, 1 year frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Hemolyzed sample - Methodology:
Nephelometry - Use:
Aid in the diagnosis of autoimmune disease, sarcoidosis, chronic liver disease, chronic and recurrent infections, lymphoid malignancies, multiple myeloma, and severe combined and variable immunodeficiencies; evaluate humoral immunity; monitor therapy in myeloma, quantitate IgG - Clinical Significance:
IgG is formed by plasma cells as a humoral immune response to contact of the immune system with antigens. The primary reaction after the initial contact is the formation of antibodies of the IgM class followed later by IgG and also IgA antibodies. Quantitative determination of the immunoglobulins can provide important information on the humoral immune status.Decreased serum immunoglobulin concentrations occur in primary immunodeficiency conditions as well as in secondary immune insufficiencies, in advanced malignant tumors, lymphatic leukemia, multiple myeloma and Waldenstrom’s disease. Increased serum immunoglobulin concentrations occur due to polyclonal or oligoclonal Ig proliferation, e.g. in hepatic diseases (hepatitis, liver cirrhosis), acute and chronic infections, autoimmune diseases as well as in the cord blood of neonates with intra-uterine and perinatal infections. Monoclonal immunoglobulin proliferations in the serum are found e.g. in plasmacytomas, Waldenstrom’s disease and heavy-chain disease. Monoclonal immunoglobulinemia requires detailed differential diagnostic investigations in addition to the quantitative determination. Local immune reactions result in elevated immunoglobulin levels, particularly IgG, in the cerebrospinal fluid. - Reference Range:
0-12 months: 232-1411 mg/dL
1-3 years: 453-916 mg/dL
4-6 years: 504-1465 mg/dL
7-9 years: 572-1474 mg/dL
10-11 years: 698-1560 mg/dL
12-13 years: 759-1550 mg/dL
14-15 years: 716-1711 mg/dL
16-19 years: 549-1584 mg/dL
≥20 years: 694-1619 mg/dL - Day Run:
Mon, Wed, Fri - Time Run:
8:00 am - Time Reported:
5:00 pm - Test Type:
IMMUNOLOGY
