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Test Name:
IgM, Quantitative, Serum
- SBMF No:
28134 - Performance Lab Name:
Immunology - Test Mnemonic:
IGM - ABN:
Not required - CPT Code:
82784 - LOINC Code:
2472-9 - Also Known As:
Immunoglobulin M, Serum - Also See:
28130 IgA, IgG, and IgM Immunoglobulins, Quantitative, Serum - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Routine venipuncture - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube
Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube - Spec Store Transport:
Refrigerated - Spec Stability:
8 days refrigerated (2-8°C) - Spec Reject:
Hemolyzed sample - Methodology:
Nephelometry - Use:
Aid in the diagnosis of abnormal protein metabolism and the body's lack of ability to resist infectious agents - Clinical Significance:
Immunoglobulins are formed by plasma cells as a humoral immune response to contact of the immune system with antigens. The primary reaction after the initial contact is the formation of antibodies of the IgM class followed later by IgG and also IgA antibodies. Quantitative determination of the immunoglobulins can provide important information on the humoral immune status.Decreased serum immunoglobulin concentrations occur in primary immunodeficiency conditions as well as in secondary immune insufficiencies, e.g., in advanced malignant tumors, lymphatic leukemia, multiple myeloma and Waldentrom’s disease. Increased serum immunoglobulins concentrations occur due to polyclonal or ligoclonal Ig proliferation, e.g., in hepatic diseases (hepatitis, liver cirrhosis), acute and chronic infections, autoimmune diseases as well as in the cord blood of neonates with intra-uterine and perinatal infections. Monoclonal immunoglobulin proliferations in the serum are found, e.g. in plasmacytomas, Waldenstrom’s disease and heavy-chain disease. Monoclonal immunoglobulinemia requires detailed differential diagnostic investigations in addition to the quantitative determination. - Reference Range:
0-12 months: 0-145 mg/dL
1-3 years: 19-146 mg/dL
4-6 years: 24-210 mg/dL
7-9 years: 32-208 mg/dL
10-11 years: 31-180 mg/dL
12-13 years: 35-239 mg/dL
14-15 years: 15-188 mg/dL
16-19 years: 23-259 mg/dL
20-60 years: 40-230 mg/dL
≥60 years: 30-360 mg/dL - Day Run:
Mon, Wed, Fri - Time Run:
8:00 am - Time Reported:
5:00 pm - Test Type:
IMMUNOLOGY
