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Test Name:
IgG, Quantitative, Cerebrospinal Fluid


  • SBMF No:
    28132
  • Performance Lab Name:
    Immunology
  • Test Mnemonic:
    CSF IGG
  • ABN:
    Not required
  • CPT Code:
    82784
  • LOINC Code:
    2464-6; 14339-6
  • Also Known As:
    Cerebrospinal Fluid IgG, Quantitative
    IgG, Cerebrospinal Fluid
    Immunoglobulin G, Cerebrospinal Fluid
  • Spec Type:
    Cerebrospinal fluid (CSF)
  • Spec Container:
    Sterile plastic tube with screw-top cap
  • Pref Vol:
    1.0 mL
  • Min Vol:
    0.5 mL
  • Fasting:
    No
  • Spec Collect:
    Collected by physician
  • Spec Process:
    Promptly centrifuge 15 minutes
    Immediately transfer supernatant to separate plastic tube
  • Spec Store Transport:
    Refrigerated
  • Spec Stability:
    8 days refrigerated (2-8°C)
  • Methodology:
    Nephelometry
  • Use:
    Detect abnormal elevations of IgG/TP
  • Clinical Significance:
    IgG is formed by plasma cells as a humoral immune response to contact of the immune system with antigens. The primary reaction after the initial contact is the formation of antibodies of the IgM class followed later by IgG and also IgA antibodies. Quantitative determination of the immunoglobulins can provide important information on the humoral immune status.
    Decreased serum immunoglobulin concentrations occur in primary immunodeficiency conditions as well as in secondary immune insufficiencies, in advanced malignant tumors, lymphatic leukemia, multiple myeloma and Waldenstrom’s disease. Increased serum immunoglobulin concentrations occur due to polyclonal or oligoclonal Ig proliferation, e.g. in hepatic diseases (hepatitis, liver cirrhosis), acute and chronic infections, autoimmune diseases as well as in the cord blood of neonates with intra-uterine and perinatal infections. Monoclonal immunoglobulin proliferations in the serum are found e.g. in plasmacytomas, Waldenstrom’s disease and heavy-chain disease. Monoclonal immunoglobulinemia requires detailed differential diagnostic investigations in addition to the quantitative determination. Local immune reactions result in elevated immunoglobulin levels, particularly IgG, in the cerebrospinal fluid.
  • Reference Range:
    0.0-5.4 mg/dL
  • Day Run:
    Mon, Wed, Fri
  • Time Run:
    8:00 am
  • Time Reported:
    5:00 pm
  • Test Type:
    CSF

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