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Test Name:
Helicobacter pylori IgG Antibody
- SBMF No:
28075 - Performance Lab Name:
Manual Lab - Test Mnemonic:
H PYL IGG - ABN:
Not required - CPT Code:
86677 - LOINC Code:
5176-3 - Also Known As:
H. pylori IgG Antibody - Spec Type:
Serum - Spec Container:
Gold top (SST) or red top (serum) tube - Pref Vol:
1.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Routine venipuncture
Parallel testing is preferred
Label samples as: "acute" or "convalescent"
Convalescent samples must be received within 30 days from receipt of acute samples - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Immediately transfer serum to separate plastic tube
Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube - Spec Store Transport:
Refrigerated - Spec Stability:
1 week refrigerated (2-8°C)
6 months frozen (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Severely hemolyzed, lipemic, or heat-inactivated specimen - Methodology:
Chemiluminescent Immunoassay (CLIA) - Use:
Increased antibody levels are associated with chronic gastritis and peptic ulcer - Clinical Significance:
The most recent clinical studies have confirmed H. pylori to be the causative agent for most cases of chronic gastritis and ulcers. In addition, there is evidence that supports the association of H. pylori with gastric carcinoma. High titer serum IgG antibody responses (and less frequently IgA responses) develop in persons colonized with H. pylori. Serologic analysis may be more sensitive than diagnostic methods involving biopsies in detecting colonization. With successful antibiotic therapy, antibodies decline to negative levels in 3-6 months. When serology is "equivocal" or when low levels of antibody are detected, confirmation by Western blot may be useful. - Reference Range:
H Pylori IgG RANGE INTERPRETATION <0.90 U/mL Negative; this result does not rule out a recent primary infection. 0.90-1.09 U/mL Indeterminate; repeat testing on a new sample in 10-14 days is recommended. > or = 1.10 U/mL Positive; indicative of previous exposure or active infection. - Additional Test Info:
Limitations: The assay should be performed only on patients with gastrointestinal symptoms due to the large percentage of H. pylori colonized individuals, especially in the older age groups.A positive result indicates the patient has antibody to H. pylori. It does not indicate that any existing symptoms are due to H. pylori infection or colonization. It also does not differentiate between active or past infection. The clinical diagnosis has to be interpreted with the clinical signs and symptoms of the patient.A negative result indicated that the patient does not have detectable levels of antibody to H. pylori. If a sample is drawn too early in H. pylori colonization, IgG antibodies may not be present. The clinical diagnosis has to be interpreted with the clinical signs and symptoms of the patient. - Day Run:
Mon, Wed, Fri - Time Run:
8:00 am - Time Reported:
5:00 pm - Test Type:
INFECTIOUS ANTIBODY
