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Test Name:
Tissue Transglutaminase IgA Antibody


  • SBMF No:
    28014
  • Performance Lab Name:
    Immunology
  • Test Mnemonic:
    TTG IGA
  • ABN:
    Not required
  • CPT Code:
    83516
  • LOINC Code:
    31017-7
  • Also Known As:
    Anti-Human Tissue Transglutaminase (Hu-tTG) IgA Recombinant Antigen
    Human Tissue Transglutaminase IgA Antibody
    h-tTG IgA Ab
    Hu-tTG IgA Ab
    tTG IgA Ab
  • Also See:
    35198 Celiac Serology Profile
    28013 Tissue Transglutaminase IgA Antibody, by ELISA, with Endomysial IgA Antibody IFA Titer if Indicated
  • Spec Type:
    Serum
  • Spec Container:
    Gold top (SST) or red top (serum) tube
  • Pref Vol:
    0.5 mL
  • Min Vol:
    0.3 mL
  • Fasting:
    No
  • Spec Collect:
    Routine venipuncture
  • Spec Process:
    Clot 30 minutes
    Promptly centrifuge 15 minutes
    Immediately transfer serum to separate plastic tube
    Properly centrifuged gel barrier tube sample does not require transfer of serum to separate tube
  • Spec Store Transport:
    Refrigerated
  • Spec Stability:
    7 days refrigerated (2-8°C)
    Greater than 7 days, freeze (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles
  • Spec Reject:
    Severely lipemic, contaminated, or hemolyzed sample
  • Methodology:
    Enzyme-Linked Immunosorbent Assay (ELISA)
  • Use:
    Detection of IgA antibodies to tissue transglutaminase (endomysium) is an aid in diagnosis of certain gluten sensitive enteropathies such as celiac disease and dermatitis herpetiformis
  • Clinical Significance:
    Celiac disease is a life-long condition in which ingestion of gluten leads to chronic inflammation and damage of the small intestinal mucosa. Tissue transglutaminase has been identified as the major autoantigen in celiac disease. IgA antibodies against tTG are highly disease specific serological markers for celiac disease and dermatitis herpetiformis.
  • Reference Range:
    0.0-7.0 U/mL

    Interpretive Data:

    < 7.0
    7.0 - 10.0
    > 10.0    		U/mL = Negative
    U/mL = Equivocal
    U/mL = Positive

  • Additional Test Info:
    NOTE: A negative tTG IgA Antibody result in an untreated patient does not rule out gluten-sensitive enteropathy. This finding can often be explained by selective IgA deficiency, a relatively frequent finding in celiac disease.
  • Day Run:
    Wed, Sat
  • Time Run:
    8:00 am
  • Time Reported:
    5:00 pm
  • Test Type:
    IMMUNOLOGY

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