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Test Name:
Zinc Protoporphyrin, Industrial, Whole Blood
- SBMF No:
23286 - Performance Lab Name:
Manual Lab - Test Mnemonic:
ZP OSHA - ABN:
Not required - CPT Code:
84202 - LOINC Code:
33007-6 - Also Known As:
ZPP
Protoporphyrin, Zinc - Also See:
23199 Lead, Industrial, Whole Blood
35152 Lead and Zinc Protoporphyrin, Industrial Exposure Profile - Spec Type:
Whole blood - Spec Container:
Dark blue (royal) top (trace metal-free - EDTA) tube
IMPORTANT: Do not use dark blue (royal) top (trace metal-free - serum) tube - Pref Vol:
7.0 mL - Min Vol:
0.5 mL - Fasting:
No - Spec Collect:
Routine venipuncture
For collection, use whole blood dark blue (royal) top tube (K2 EDTA additive, trace metal-free)
– IMPORTANT: Do not use dark blue (royal) top serum tube (no additive, trace metal-free)
Avoid specimen contact with any metallic surface except the stainless steel collection needle
If more than 1 test ordered, collect tube for ZPP first
Immediately after collection, gently invert tube to mix
Label sample tube
Wrap labeled tube in foil to protect from light exposure
Do not place specimen label over foil wrap - Spec Process:
Do not centrifuge
Do not remove plasma from cells - Spec Store Transport:
Refrigerated - Spec Stability:
24 hours room temperature (20-30°C)
1 week refrigerated (2-8°C)
Frozen: Unacceptable - Spec Reject:
Hemolyzed sample
Sample collected in trace metal-free serum tube - Methodology:
Front-Surface Fluorometry - Use:
Monitoring iron metabolism - Clinical Significance:
The porphyrias are a group of genetic abnormalities of heme synthesis in which abnormal concentrations of heme precursors accumulate. Many conditions that interfere with iron metabolism in the developing erythrocyte will induce an increase in ZPP and porphyrins. Such conditions include chronic inflammatory processes, iron deficiency, and lead exposure. Depending upon clinical circumstances, other tests, such as whole blood lead or serum ferritin, may be necessary for evaluation. Serum porphyrins are more specific for inherited porphyrin disorders, such as erythropoietic protoporphyria. Zinc protoporphyrin (ZPP) accumulates in erythrocytes as a result of chronic lead absorption or iron deficiency anemia. - Reference Range:
- Zinc Protoporphyrin, Industrial, Whole Blood
- ZPP OSHA Occupational threshold: <100 µg ZP/dL blood.
It is recommended that a hematocrit be determined whenever a confirmed ZPP of 50 µg ZP/dL whole blood is obtained to rule out a significant underlying anemia.
OSHA requires ZPP whole blood testing in units of µg/dL.
- Day Run:
Mon, Tue, Thu, Fri - Time Run:
8:00 am - Time Reported:
5:00 pm - Test Type:
CHEMISTRY
