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Test Name:
5-Hydroxyindoleacetic Acid, Quantitative, Urine, Random
- SBMF No:
23238 - Performance Lab Name:
Manual Lab - Test Mnemonic:
U 5HIAA R - ABN:
Not required - CPT Code:
83497 - LOINC Code:
2161-8; 1694-9; 11145-0 - Test Includes:
5-Hydroxyindoleacetic Acid
Creatinine - Also Known As:
5-HIAA
Serotonin metabolite - Also See:
23236 5-Hydroxyindoleacetic Acid, Quantitative, Urine, 24-Hour - Spec Type:
Urine, random - Spec Container:
Plastic container with tightly fitting lid (no preservative) - Pref Vol:
10.0 mL urine aliquot from well-mixed urine specimen - Min Vol:
4.0 mL urine aliquot from well-mixed urine specimen - Fasting:
No - Patient Prep:
For 72 hours prior to and during collection, observe the following restrictions:
- Dietary: avoid avocados, bananas, eggplant, pineapple, plums, tomatoes, or walnuts
- Other: avoid medications, over-the-counter drugs, or herbal remedies - Spec Collect:
Routine random urine collection - Spec Process:
Transport refrigerated urine immediately - Spec Store Transport:
Refrigerated - Spec Stability:
1 week refrigerated (2-8°C) - Spec Reject:
Addition of HCl to urine sample is cause for rejection - Methodology:
High Performance Liquid Chromatography (HPLC) - Use:
Diagnosis of carcinoid tumors - Clinical Significance:
Carcinoids are the most common tumors arising from the diffuse neuroendocrine system of the GI tract and pancreas. As with normal gut endocrine cells, carcinoids synthesize, store, and release a variety of hormones and biogenic amines. Serotonin is one of the best characterized among these substances.
Overproduction of serotonin is found in 90 to 100% of patients with carcinoid syndrome. Measurement of serotonin and its metabolites in body fluid and tissue is important in the evaluation of this syndrome. Serotonin is converted to the metabolite, 5-hydroxyindoleacetic acid (5-HIAA), and is excreted by the kidneys. As a result, urinary determination of 5-HIAA is the most frequently used test for the diagnosis of carcinoid syndrome.
In pathological conditions, 5-HIAA is excreted in very large amounts, often exceeding 350 mg/day. However, it is critical to use a more sensitive 5-HIAA method for early diagnosis when tumors are small and not metastasized. 5-HIAA excretion values of these tumors barely exceed 8 mg/day. SBMF is replacing the previous qualitative method with a new, more sensitive, quantitative method for 5-HIAA. - Reference Range:
0.0–14.0 mg/g creatinine - Day Run:
Wed, Sat - Time Run:
7:00 am - Time Reported:
5:00 pm - Test Type:
HORMONE
