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Test Name:
Kappa/Lambda Free Light Chains, Quantitative, with Ratio, Urine, 24-Hour
- SBMF No:
23219 - Performance Lab Name:
Manual Lab - Test Mnemonic:
U K/L QNT - ABN:
Not required - CPT Code:
83883x2 - LOINC Code:
53574-0; 43940-6; 49908-7 - Also See:
23064 Immunofixation, Urine
23273 Protein Electrophoresis, Urine, 24-Hour - Spec Type:
Urine, 24-hour - Spec Container:
Plastic container with tightly fitting lid (no preservative) - Pref Vol:
5.0 mL aliquot from well-mixed 24-hour collection
Note: Send urine aliquot with notation of 24-hour volume on aliquot label and on requisition - Min Vol:
1.0 mL aliquot from well-mixed 24-hour collection - Fasting:
No - Spec Collect:
To begin collection of timed specimen, have patient urinate, noting date and exact time
Discard this first portion of urine, but document date and time of voiding on container label and test requisition as "start" of timed specimen
Save all urine voided during designated time period, including portion voided at exact end of time period
IMPORTANT: Refrigerate entire specimen (2-8°C) during and after collection to prevent bacterial growth
Document date and time of final voiding on label and requisition as "end" of timed specimen - Spec Process:
Upon completion of collection, mix entire specimen well and measure 24-hour volume
Pour off 5.0 mL of urine into separate plastic tube
Refrigerate urine aliquot and transport refrigerated
Send urine aliquot with notation of entire 24-hour urine volume on aliquot label and on requisition - Spec Store Transport:
Refrigerated - Spec Stability:
3 weeks (21 days) refrigerated (2-8°C)
Greater than 3 weeks, freeze (-20°C) – do not use frost-free units that undergo repeated freeze/thaw cycles - Methodology:
Latex-Enhanced, Nephelometric Immunoassay - Use:
Measurements of free light chains in serum or urine aid in the diagnosis and monitoring of multiple myeloma, lymphocytic neoplasms, Waldenstrom’s macroglobulinemia, amyloidosis, light chain deposition disease, and connective tissue diseases such as systemic lupus erythematosus. - Clinical Significance:
Free light chains (FLC) is a more sensitive test than serum or urine immunofixation (IF) and it is a valuable tool for diagnosing and monitoring patients with secretory and nonsecretory multiple myeloma. Nearly all multiple myeloma patients have increased FLC. Monitoring of FLC provides a quicker indication of response to therapy than monoclonal or total immunoglobulins due to its shorter half-life and the larger clinical ranges of FLC concentrations. 100% of patients with light-chain multiple myeloma, 75% with nonsecretory myeloma, and more than 95% with primary amyloidosis could be diagnosed using FLC. - Reference Range:
Free Kappa: 1.35-24.19 mg/L
Free Lambda: 0.24-6.66 mg/L
Ratio Kappa/Lambda: 2.040-10.370 - Day Run:
Tue, Thu, Sat - Time Run:
8:00 am - Time Reported:
5:00 pm - Test Type:
URINE
