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Test Name:
Zinc, Serum
- SBMF No:
23182 - Performance Lab Name:
Manual Lab - Test Mnemonic:
ZINC- - ABN:
Not required - CPT Code:
84630 - LOINC Code:
5763-8 - Also Known As:
Zn - Spec Type:
Serum - Spec Container:
Dark blue (royal) top tube (trace element-free - serum) provided in SBMF “Trace Metal Collection Kit” (order SBMF stock #7208)
IMPORTANT: Do not use dark blue (royal) top (EDTA) tube - Pref Vol:
3.0 mL - Min Vol:
1.0 mL - Fasting:
No - Spec Collect:
Use SBMF "Trace Metal Collection Kit"
Routine venipuncture
Avoid specimen contact with any metallic surface except the stainless steel collection needle
If more than 1 test ordered, collect tube for zinc first - Spec Process:
Clot 30 minutes
Promptly centrifuge 15 minutes
Within 60 minutes of collection time, “pour off” serum into the metal-free plastic vial provided in the SBMF “Trace Metal Collection Kit”
Do not use pipettes or wooden sticks to aid in specimen transfer
If specimen will not be received at SBMF within 48 hours of collection, freeze - Spec Store Transport:
Refrigerated (48 hours) or frozen - Spec Stability:
48 hours refrigerated (2-8°C)
Greater than 48 hours, freeze (-20°C) – Do not use frost-free units that undergo repeated freeze/thaw cycles - Spec Reject:
Hemolyzed sample
Specimen in contact with metal during collection or processing
Serum transferred to unacceptable container
Serum not transferred to vial within 60 minutes of collection
Serum not frozen within 48 hours of collection - Methodology:
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) - Use:
Evaluate nutritional status - Clinical Significance:
Zinc is an essential element; it is a critical cofactor for carbonic anhydrase, alkaline phosphatase, RNA and DNA polymerases, alcohol dehydrogenase, and many other physiologically important proteins. The peptidases, kinases and phosphorylases are most sensitive to zinc depletion. Zinc is a key element required for active wound healing.Zinc depletion occurs because either it is not absorbed from the diet or it is lost after absorption. Dietary deficiency may be due to absence (parenteral nutrition) or because the zinc in the diet is bound to phyate (fiber) and not available for absorption. Once absorbed, the most common route of loss is via exudates from open wounds such as third degree burn or gastrointestinal loss as in colitis. Hepatic cirrhosis causes excess loss of zinc by enhancing renal excretion. Zinc depletion occurs in burn patients who loose zinc in the exudates from their burn sites.Zinc excess is not a major clinical concern. The popular American habit of taking mega-vitamins (containing huge doses of zinc) produces no direct toxicity problems. Much of this zinc passes through the gastrointestinal tract and is excreted in the feces. The excess fraction that is absorbed is excreted in the urine. The only known effect of excessive zinc ingestion relates to the fact that zinc interferes with copper absorption that can lead to hypocupremia. - Reference Range:
Normal: 700-1200 μg/L - Day Run:
Wed, Sat - Time Run:
8:00 am - Time Reported:
5:00 pm - Test Type:
CHEMISTRY
